Our understanding of the key drivers of rheumatoid arthritis (RA) disease onset and progression has matured to include both pathogenic antibodies and proinflammatory cytokines. "RA, redefined" is an educational initiative for rheumatologists who diagnose and treat patients with RA that provides information on our evolved comprehension of the pathogenic drivers of this destructive disease.
Do Autoantibodies Drive Disease in Seropositive RA?
RA is an autoimmune disease. In RA, the perpetuation of B cell–derived autoantibodies and proinflammatory cytokines drives disease progression. Immune cells, including T cells, B cells, and macrophages, are critical components in this cycle.
RA is driven by pathogenic antibodies and proinflammatory cytokines. Recent research has redefined our understanding of the disease and the underlying factors behind the articular and extra-articular manifestations of RA.